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睡眠在维持正常的学习和记忆过程中起关键作用。当前世界范围内睡眠不足问题非常普遍,长期睡眠不足会导致机体功能紊乱,引发神经认知功能障碍性疾病。关于睡眠不足影响学习记忆功能的机制尚不明确。最新研究表明睡眠剥夺会通过诱导异常自噬损伤海马神经元结构、基因组转录和翻译,调控cPKCγ-Ng信号通路、调节突触可塑性等机制损害学习记忆。急性短期睡眠剥夺还可通过诱导早期生长应答因子3、脑源性神经营养因子表达及增加老年大鼠海马纺锤波数量等机制改善学习记忆。本文拟就睡眠剥夺对学习记忆的优劣影响及机制作一综述,以期为后续研究提供参考。
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基本信息:
DOI:
中图分类号:R740
引用信息:
[1]杨丽丽,张晓爽,解雅英.睡眠剥夺对学习记忆的影响及机制研究进展[J].巴楚医学,2022,5(03):124-128.
基金信息:
内蒙古卫健委卫生健康科技项目(No:202201265 A类)