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以手术切除、放射治疗和化学治疗为代表的传统肿瘤治疗模式，在晚期实体瘤患者预后改善方面面临显著瓶颈。随着肿瘤分子生物学研究不断深入，多种关键分子靶点和异常激活信号转导通路被相继阐明，为个体化精准靶向治疗提供理论依据。在靶向治疗技术领域，超声联合生物素化微泡创新策略展现出广阔的应用前景。该技术体系将超声生物学效应与分子靶向巧妙融合，对微泡表面进行生物素化修饰后，利用生物素-亲和素系统桥梁，实现与亲和素偶联的肿瘤特异性配体/抗体定向组装。在此基础上，通过超声靶向微泡爆破技术，精准递送治疗性药物或基因至表达特异性抗原的肿瘤细胞。本文将从生物素化靶向微泡构建、靶向机制及其在肿瘤治疗中的应用进行系统性综述。
Abstract：Traditional cancer treatment modalities, including surgical resection, radiotherapy, and chemotherapy, face significant challenges in improving the prognosis of patients with advanced solid tumors. With the continuous progress in tumor molecular biology, multiple key molecular targets and aberrantly activated signaling pathways have been elucidated, providing a theoretical foundation for individualized precision-targeted therapy. In the field of targeted therapy, the innovative strategy of ultrasound-assisted biotinylated microbubbles has demonstrated promising application prospects. This technology integrates the biological effects of ultrasound with molecular targeting by modifying the microbubble surface with biotin. Utilizing the biotin-avidin system as a molecular bridge, tumor-specific ligands or antibodies conjugated with avidin can be directionally assembled onto the microbubble surface. Based on this approach, ultrasound-targeted microbubble destruction enables the precise delivery of therapeutic drugs or genes to tumor cells expressing specific antigens. This review provides a systematic overview of the construction of biotinylated targeted microbubbles, targeting mechanisms and applications in tumor therapy.
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基本信息:
中图分类号:R730.5
引用信息:
[1]杨丹,徐世瑾,周畅,等.生物素化微泡构建在肿瘤靶向治疗中的应用进展[J].巴楚医学,2025,8(04):119-123.
基金信息:
湖北省自然科学基金青年项目(2023AFB137); 湖北省教育厅青年人才项目(Q20231202); 肿瘤微环境与免疫治疗湖北省重点实验室开放基金项目(2023KZL031)
2025-12-30
2025-12-30