巴楚医学

目的：评价亚甲蓝封闭联合不同干预措施对肛周湿疹的应用效果。方法：检索The Cochrane Library, PubMed, Embase, Web of Science等英文数据库及中国知网期刊全文数据库(CNKI)、中文科技期刊数据库(VIP)、万方医学数据库等中文数据库中关于亚甲蓝封闭联合不同措施对肛周湿疹临床疗效的随机对照试验(RCTs),检索时限为各数据库建库至2022年1月。经过文献筛选，提取数据，使用RevMan5.4软件及R-4.0.2软件进行网状Meta分析。结果：纳入9项RCTs,共涉及5项干预措施。与单独使用亚甲蓝封闭相比，亚甲蓝封闭+中药熏洗坐浴(RR=1.20,95%CI:1.05,1.36)、亚甲蓝封闭+中药熏洗+耳穴(RR=1.89,95%CI:1.32,2.71)以及亚甲蓝封闭+湿疹方内服外用(RR=1.20,95%CI:1.02,1.40)疗效更显著(均P<0.05)。亚甲蓝封闭+中药熏洗+耳穴(0.983)在综合疗效排序中分值最高。结论：在常规亚甲蓝封闭治疗的基础上，联合中药熏洗以及耳穴贴压可能提高肛周湿疹的临床治疗效果。

Objective: To evaluate the effect of methylene blue local blocking combined with different intervention measures on perianal eczema. Methods: Randomized controlled trials(RCTs) on the application effect of methylene blue partial blocking combined with different interventions on perianal eczema were retrieved from databases, including, The Cochrane Library, PubMed, Embase, Web of Science, CNKI, Chinese Scientific and Technical Journal Database(VIP) and Wanfang Database. The retrieval time is from the establishment of each database to January 2022. After literature screening and data extraction, RevMan 5.4 software and R-4.0.2 software were used for frequency network meta-analysis. Results: A total of 9 RCTs with 5 interventions were included. Compared with methylene blue alone, methylene blue blocking therapy + Traditional Chinese Medicine(TCM) fumigation(RR=1.20,95%CI:1.05,1.36), methylene blue blocking + TCM fumigation + auricular acupoint(RR=1.89,95%CI:1.32,2.71) and methylene blue blocking + TCM internal and external use(RR=1.20,95%CI:1.02,1.40) had more significant efficacy(all P<0.05). Methylene blue blocking+TCM fumigation+auricular acupoint(0.983) had the highest score in the ranking of comprehensive efficacy. Conclusion: Based on the conventional methylene blue blocking treatment, combined with TCM fumigation and auricular point may enhance the clinical curative effect of perianal eczema.