巴楚医学

目的：探讨宫颈液基薄层细胞学检查(TCT)和人乳头瘤病毒(HPV)-DNA筛查宫颈病变的价值。方法：选取2017年3月～2021年3月在本院进行宫颈病变筛查的2 730例女性，以病理学检查为临床诊断金标准，采用Kappa一致性检验比较TCT与HPV-DNA筛查的灵敏度、特异度、准确度和阳性预测值。结果：2 730例女性经TCT和HPV-DNA共检出阳性83例，再次经病理确诊62例宫颈病变患者，其中TCT确诊49例，HPV-DNA确诊51例。与病理学检查相比，TCT、HPV-DNA筛查宫颈病变的Kappa值分别为0.625、0.670,敏感度分别为79.03%、82.26%,特异度均为95.24%,准确率分别为83.13%、85.54%,阳性预测值分别为98.00%、98.08%,TCT联合HPV-DNA筛查宫颈病变的阳性预测值为74.70%。结论：TCT、HPV-DNA筛查宫颈病变均有较高的价值，联合检测可提高阳性患者检出率。

Objective: To investigate the value of cervical liquid based thinprep cytology test(TCT) and human papillomavirus(HPV)-DNA in screening cervical lesions. Methods: A total of 2 730 women who were screened for cervical lesions in our hospital from March 2017 to March 2021 were selected. Taking pathological examination as the gold standard for clinical diagnosis, kappa consistency test was used to compare the sensitivity, specificity, accuracy and positive predictive value of TCT and HPV-DNA screening. Results: A total of 83 cases were positive by TCT and HPV-DNA, and 62 cases were confirmed by pathology, including 49 cases by TCT, 51 cases by HPV-DNA. Compared with pathological examination, the kappa values of TCT and HPV-DNA screening for cervical lesions were 0.625 and 0.670, with the sensitivity of 79.03% and 82.26%, the specificity of 95.24%, the accuracy of 83.13% and 85.54%, and the positive predictive values of 98.00% and 98.08%, respectively. The positive predictive value of TCT combined with HPV-DNA screening for cervical lesions was 74.70%.Conclusion: TCT and HPV-DNA are of high value in screening cervical lesions. Combined examination can improve the detection rate of positive patients.