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目的:探讨改良栀子制剂治疗急性外侧踝关节扭伤的临床疗效。方法:回顾性分析2024年5月—2024年11月于宜昌市中心人民医院就诊的44例急性外侧踝关节扭伤的患者。根据治疗方法不同,分为观察组(n=22)和对照组(n=22),其中观察组采用标准化改良栀子制剂,对照组采用不含栀子提取物的安慰剂。比较两组患者治疗1周后的临床疗效。结果:观察组患者皮纹征出现时间[(2.96±0.68) d vs (4.75±1.07) d]早于对照组,视觉模拟量表评分[(2.76±0.83)分vs(4.80±0.62)分]明显低于对照组,美国足踝外科协会踝关节-后足评分[(79.88±0.52)分vs(63.55±3.46)分]明显高于对照组(均P<0.05)。观察组患者血清白细胞介素-1β及肿瘤坏死因子-α均低于对照组(均P<0.05)。两组患者临床满意度无明显差异(P>0.05)。结论:改良栀子制剂可有效减轻急性外侧踝关节扭伤患者的局部肿胀、炎症水平和疼痛程度,改善患者的踝关节活动功能。
Abstract：Objective:To investigate the clinical efficacy of modified gardenia preparations in the treatment of acute lateral ankle sprains.Methods:A retrospective analysis was conducted on 44 patients with acute lateral ankle sprains who were treated at Yichang Central People's Hospital from May to November 2024.Patients were divided into an observation group(n=22) and a control group(n=22) based on different treatment methods.The observation group received standardized modified gardenia preparations,while the control group received a placebo without gardenia extract.The clinical outcomes of both groups were compared after one week of treatment.Results:The appearance time of skin crease sign in the observation group [(2.96±0.68) d vs(4.75 ± 1.07) d] was earlier than that in the control group.The visual analogue scale score[(2.76±0.83) points vs(4.80±0.62) points] was significantly lower,and the American Orthopaedic Fool and Ankle Society ankle-hindfoot score [(79.88 ± 0.52) points vs(63.55 ± 3.46) points] was significantly higher than those in control group(all P<0.05).Serum levels of interleukin-1 β and tumor necrosis factor-αin the observation group were lower than those in the control group(both P < 0.05).There was no significant difference in clinical satisfaction between the two groups(P> 0.05).Conclusion:Modified gardenia preparations can effectively reduce local swelling,inflammation levels,and pain in patients with acute lateral ankle sprains,and improve ankle joint function.
[1]Wikstrom E A,Cain M S,Chandran A,et al.Lateral ankle sprain and subsequent ankle sprain risk:a systematic review[J].J Athl Train,2021,56(6):578-585.
[2]Saki F,Yalfani A,Fousekis K,et al.Anatomical risk factors of lateral ankle sprain in adolescent athletes:a prospective cohort study[J].Phys Ther Sport,2021,48:26-34.
[3]Song J H,Moon J J,Shin W J,et al.Use of a comprehensive systemic ultrasound evaluation in the diagnosis and analysis of acute lateral region ankle sprain[J].BMC Musculoskelet Disord,2023,24(1):517.
[4]Ortega-Avila A B,Cervera-Garvi P,MarchenaRodriguez A,et al.Conservative treatment for acute ankle sprain:a systematic review[J].J Clin Med,2020,9(10):3128.
[5]Dubois B,Esculier J F.Soft-tissue injuries simply need PEACE and LOVE[J].Br J Sports Med,2020,54(2):72-73.
[6]Harrasser N,Toepfer A.Bandverletzungen des oberen sprunggelenks[J].Die Orthop?die,2024,53(3):223-233.
[7]Yokoe T,Tajima T,Yamaguchi N,et al.The current clinical practice of general orthopaedic surgeons in the treatment of lateral ankle sprain:a questionnaire survey in Miyazaki,Japan[J].BMC Musculoskelet Disord,2021,22(1):636.
[8]Aicale R,Maffulli N.Chronic lateral ankle instability:topical review[J].Foot Ankle Int,2020,41(12):1571-1581.
[9]Michels F,Wastyn H,Pottel H,et al.The presence of persistent symptoms 12 months following a first lateral ankle sprain:a systematic review and meta-analysis[J].Foot Ankle Surg,2022,28(7):817-826.
[10]中华医学会运动医疗分会,中华医学会骨科学分会,中华医学会物理医学与康复学分会,等.运动系统损伤外用NSAIDs治疗的临床实践指南(2024版)[J].中国循证医学杂志,2024,24(5):497-509.
[11]Deng R,Wu H,Wang Y,et al.Properties and molecular mechanisms underlying geniposide-mediated therapeutic effects in chronic inflammatory diseases[J].J Ethnopharmacol,2021,27 3:113958.
[12]徐玉德,谢兴文,董林,等.民间验方栀子蛋清方治疗急性踝关节软组织损伤的临床观察[J].甘肃医药,2015,34(7):491-494.
[13]吕江华,杨华瑞,刘万军,等.栀子蜂蜜膏外敷治疗兔急性软组织损伤的实验研究[J].中国中医骨伤科杂志,2017,25(8):6-10.
[14]邵青森,黄豪,梁锋,等.栀子花中化学成分及药理作用研究进展[J].云南民族大学学报(自然科学版),2025,34(1):1-12.
[15]Chowdhury A,Azam S,Jainul M A,et al.Antibacterial activities and in vitro anti-inflammatory(membrane stability)properties of methanolic extracts of Gardenia coronaria leaves[J].Int J Microbiol,2014,2014:410935.
[16]Sung Y Y,Lee A Y,Kim H K.The Gardenia jasminoides extract and its constituent,geniposide,elicit anti-allergic effects on atopic dermatitis by inhibiting histamine in vitro and in vivo[J].J Ethnopharmacol,2014,156:33-40.
[17]Deng R,Li F,Wu H,et al.Anti-inflammatory mechanism of geniposide:inhibiting the hyperpermeability of fibroblast-like synoviocytes via the RhoA/p38MAPK/NF-κB/F-actin signal pathway[J].Front Pharmacol,2018,9:105.
基本信息:
中图分类号:R684.7
引用信息:
[1]邹亮,寿康全,张恒,等.改良栀子制剂治疗急性外侧踝关节扭伤的临床疗效分析[J].巴楚医学,2025,8(03):42-46.
基金信息:
湖北省自然科学基金项目(2021CFB488); 湖北省卫生计生委西医类重点资助项目(WJ2015MA025); 宜昌市医疗卫生研究项目(A24-2-007)
2025-09-28
2025-09-28