巴楚医学

目的：采用益肾通络方治疗早中期慢性肾功能衰竭患者，验证其有改善肾功能、延缓疾病进展方面的疗效。方法：本研究共纳入120例早中期慢性肾功能衰竭患者，随机分为治疗组和对照组，每组各60例。对照组采用纯西医药物治疗，治疗组在对照组治疗的基础上，加用益肾通络方。所有患者规律治疗1个月。治疗前后监测尿素氮(BUN)、血肌酐(Scr)及肾小球滤过率(GFR)变化。结果：经治疗后，治疗组的BUN、Scr、GFR均明显优于对照组(均P<0.05)。治疗组治疗总有效率为50.00%,明显高于对照组26.67%(P<0.05)。结论：益肾通络方联合西医基础治疗能显著降低早中期慢性肾功能衰竭患者的BUN和Scr,提高GFR,延缓肾功能恶化。

Objective: Tonifying kidney and dredging collaterals prescription is used in the treatment of patients with early and middle stage chronic renal failure. This article aims to verify the efficacy of tonifying kidney and dredging collaterals in improving renal function and delaying disease progression. Methods: A total of 120 patients with early and middle stage of chronic renal failure were enrolled and randomly divided into the treatment group and the control group, with 60 cases in each group. The control group were treated with pure Western medicine, while the treatment group were treated with tonifying kidney and dredging collaterals prescription in addition to the Western medicine. All patients were regularly treated for one month. Blood urea nitrogen(BUN), serum creatinine(Scr) and glomerular filtration rate(GFR) were monitored before and after treatment. Results: Compared to the control group, BUN, Scr and GFR in the treatment group were significantly better(all P<0.05). The effective rate was 50.00% in the treatment group, which was significantly higher than 26.67% in the control group(P<0.05). Conclusion: Tonifying kidney and dredging collaterals prescription combined with Western medicine can significantly reduce Scr and BUN, increase GFR and delay the deterioration of renal function on early and middle stage of chronic renal failure.