巴楚医学

目的:回顾性分析我院系统性红斑狼疮(SLE)合并消化系统损伤患者的临床特点及其影响因素。方法:选择2017年1月~2018年6月我院收治的271例SLE患者,其中168例(61.99%)合并消化系统损伤,103例(38.01%)未合并消化系统损伤。统计入组患者的一般资料、临床表现及相关实验室指标,分析SLE合并消化系统损伤的危险因素。结果:合并消化系统损伤的168例SLE患者中,155例(92.26%)以消化系统以外的皮疹、发热、肾功能损伤、关节炎、心包炎及胸膜炎等为主要起始症状,13例(7.74%)以消化系统的腹胀、腹痛、腹泻、腹水、恶心呕吐及食欲不振等为主要起始症状。患者主要表现包括食欲不振(84.52%)、肝损伤及肝功能异常(50.60%)、腹痛(35.12%)、腹胀(31.55%)、恶心呕吐(29.17%)、腹水(28.57%)、腹泻(17.26%)、消化道出血(14.29%)和吞咽困难(5.36%)。其中食欲不振是SLE合并消化道系统损伤最常见的临床症状。此外,合并呼吸系统疾病、泌尿系统疾病、抗中性粒细胞胞浆抗体阳性、血清白蛋白水平降低是SLE合并消化系统损伤的独立危险因素(均P<0.05)。结论:SLE患者易合并消化系统损伤,主要表现为食欲不振、肝功能异常、腹痛腹胀、恶心呕吐等。合并呼吸系统疾病、泌尿系统疾病、抗中性粒细胞胞浆抗体阳性及血清白蛋白水平降低的SLE患者更容易合并消化系统损伤。

Objective:To analyze the clinical characteristics and influencing factors of patients with systemic lupus erythematosus(SLE)complicated with digestive system injury in our hospital.Methods:A total of 271 cases of SLE admitted to our hospital from January 2017 to June 2018,including 168(61.99%)patients with digestive system injury and 103(38.01%)patients without that were enrolled in the study.General data,clinical manifestations and relevant laboratory indexes were collected to analyze the risk factors of SLE complicated with digestive system injury.Results:Among the 168 cases of SLE complicated with digestive system injury patients,there were 155(92.26%)patients performed with rash,fever,kidney damage,arthritis,pericarditis and pleurisy as the main initial symptoms,and 13(7.74%)patients performed with abdominal distension,abdominal pain,diarrhea,ascites,nausea,vomiting and anorexia as the main first symptoms.The main manifestations contained anorexia(84.52%),liver injury and abnormal liver function(50.60%),abdominal pain(35.12%),abdominal distension(31.55%),nausea and vomiting(29.17%),ascites(28.57%),diarrhea(17.26%),gastrointestinal bleeding(14.29%)and dysphagia(5.36%).Anorexia was the most common symptom of SLE complicated with gastrointestinal system injury.In addition,respiratory diseases,urinary system diseases,positive anti-neutrophilic cytoplasmic antibodies and decreased serum albumin levels were independent risk factors for SLE with digestive system injury(All P<0.05).Conclusion:Patients with SLE tend to be complicated with digestive system injury,which is mainly manifested by a series of symptoms including anorexia,abnormal liver function,abdominal pain and distension,nausea,vomiting and so on.SLE patients with respiratory diseases,urinary system diseases,positive anti-neutrophil cytoplasmic antibodies and reduced serum albumin levels are more likely to be associated with digestive system injury.