| 170 | 5 | 168 |
| 下载次数 | 被引频次 | 阅读次数 |
目的:评估利多卡因凝胶贴膏联合盐酸曲马多缓释片在带状疱疹后神经痛(PHN)中的应用效果。方法:选取2018年2月-2021年2月我院收治的80例PHN患者,采用简单随机分组法将患者分为观察组和对照组,每组各40例。对照组采用普瑞巴林联合盐酸曲马多缓释片治疗,观察组采用利多卡因凝胶贴膏联合盐酸曲马多缓释片治疗,均持续治疗1个月。评估患者治疗的临床疗效、睡眠质量和疼痛程度,并记录患者治疗期间不良反应的发生率。结果:治疗后,观察组总有效率为90.00%,与对照组的75.00%相比,差异无统计学意义(P>0.05)。治疗15天和1个月后,观察组的匹茨堡睡眠质量指数量表(PSQI)评分和视觉模拟(VAS)评分均显著低于对照组(均P<0.05)。观察组治疗期间不良反应的发生率为10.00%,与对照组的22.50%相比,差异无统计学意义(P>0.05)。结论:利多卡因凝胶贴膏联合盐酸曲马多缓释片治疗PHN的疗效确切,可改善患者的睡眠质量。
Abstract：Objective:To explore the effects of lidocaine cataplasm combined with tramadol hydrochloride sustained-release tablets in post-herpetic neuralgia(PHN).Methods:A total of 80 patients with PHN in our hospital between February 2018 and February 2021 were enrolled.According to simple random grouping method,they were divided into the observation group and the control group,with 40 cases in each group.Patients in the control group were treated with pregabalin combined with tramadol hydrochloride sustainedrelease tablets,while the observation group were treated with lidocaine cataplasm combined with tramadol hydrochloride sustained-release tablets.Both groups were continuously treated for 1 month.The clinical curative efficacy,sleep quality and pain degree were evaluated.The incidence of adverse reactions during treatment was recorded.Results:There was no significant difference in total response rate between the observation group and the control group(90.00% Vs 75.00%,P>0.05).After 15 days and 1 month of treatment,scores of Pittsburgh sleep quality index(PSQI)and visual analogue scale(VAS)in the observation group were significantly lower than those in the control group(both P<0.05).There was no significant difference in the incidence of adverse reactions during treatment between these two groups(10.00% Vs 22.50%,P >0.05).Conclusion:Lidocaine cataplasm combined with tramadol hydrochloride sustained-release tablets is effective in the treatment of PHN,which can improve sleep quality of patients.
[1] Saguil A,Kane S,Mercado M,et al.Herpes zoster and postherpetic neuralgia:prevention and management[J].Am Fam Physician,2017,96(10):656-663.
[2] Ngo A L,Urits I,Yilmaz M,et al.Postherpetic neuralgia:current evidence on the topical film-forming spray with bupivacaine hydrochloride and a review of available treatment strategies[J].Adv Ther,2020,37(5):2003-2016.
[3]孙付国，叶菱，陈璐，等．利多卡因乳膏介导体外冲击波治疗带状疱疹后神经痛的可行性及有效性[J]．武警医学，2021,32(3):205-208.
[4]刘奎玲，李晓强，孙雪华．利多卡因凝胶贴膏联合加巴喷丁治疗带状疱疹后神经痛[J]．中国疼痛医学杂志，2021,27(5):386-389.
[5]林志淼，杨勇，李若瑜．带状疱疹及后遗神经痛[J]．临床皮肤科杂志，2010,39(6):393-395.
[6] Kato J,Matsui N,Kakehi Y,et al.Mirogabalin for the management of postherpetic neuralgia:a randomized,double-blind,placebo-controlled phase 3study in Asian patients[J].Pain,2019,160(5):1175-1185.
[7] Mallick-Searle T,Snodgrass B,Brant J M.Postherpetic neuralgia:epidemiology,pathophysiology,and pain management pharmacology[J].J Multidiscip Healthc,2016,9:447-454.
[8] Xing X F,Zhou Z F,Zhang F J,et al.The effect of early use of supplemental therapy on preventing postherpetic neuralgia:a systematic review and meta-analysis[J].Pain Physician,2017,20(6):471-486.
[9] Hussain N,Said A S A,Javaid F A,et al.The efficacy and safety profile of capsaicin 8%patch versus 5%Lidocaine patch in patients with diabetic peripheral neuropathic pain:a randomized,placebo-controlled study of south Asian male patients[J].J Diabetes Metab Disord,2021,20(1):271-278.
[10]Liu F,Lu G J,Bai Z Y.Efficacy of repetitive paravertebral block combined with medication in the treatment of zoster-related pain with different courses[J].Neurosciences(Riyadh),2021,26(2):192-198.
[11]毕连红，马先鹏．利多卡因凝胶治疗带状疱疹后神经痛临床疗效分析[J]．北华大学学报（自然科学版），2017,18(1):94-96.
[12]Knezevic N N,Tverdohleb T,Nikibin F,et al.Management of chronic neuropathic pain with single and compounded topical analgesics[J].Pain Manag,2017,7(6):537-558.
基本信息:
中图分类号:R752.12
引用信息:
[1]盛志锋,张爱萍,邹鲁,等.利多卡因凝胶贴膏联合盐酸曲马多缓释片在PHN中的应用[J].巴楚医学,2021,4(04):50-53.
基金信息:
江苏省高校哲学社会科学基金（No:2017SJB0273）
2021-12-30
2021-12-30