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细菌感染是临床常见的疾病问题之一,而细菌耐药性的出现则进一步增大了治疗难度。随着抗生素的广泛使用,细菌耐药性问题日益严重,寻找新的抗菌药物和抗菌机制成为当前研究的热点。由于新型抗生素研发难度较大,促使天然植物活性成分成为抗菌研究新热点。这些成分来源广、毒性低、耐药风险小,且研发成本低,具有巨大发展潜力。冬凌草是一种天然植物,其提取物和主要活性成分冬凌草甲素具有显著抗菌活性,近年来,因其对多种耐药菌株表现出良好抑制作用及广谱抗菌潜力,受到广泛关注。本文综述了近五年国内外有关冬凌草的主要抗菌成分、抗菌活性、抗菌机制及其抗耐药菌作用的研究进展,以期为冬凌草抗菌机制和逆转细菌耐药性的潜在机制提供参考。
Abstract：Bacterial infection is one of the common clinical diseases, and the emergence of bacterial resistance has brought great challenges to clinical treatment. With the extensive use of antibiotics, the problem of bacterial resistance has become more and more serious, and the search for new antibacterial drugs and antibacterial mechanisms has become a hot spot in current research. The difficulty in the development of new antibiotics has led to the emergence of natural plant active ingredients as a new hotspot in antibacterial research. These ingredients are widely available, low toxicity, low risk of drug resistance, and low research and development costs, and have great potential for development. Rabdosia Rubescens is a natural plant, and its extract and active ingredient,oridonin, have significant antimicrobial activity, which has received extensive attention in recent years due to its inhibitory effect on the increasing number of drug-resistant bacteria and strong broad-spectrum antimicrobial effect. This review summarizes recent progress on the antibacterial components, activities, mechanisms, and effects against drug-resistant bacteria of Rabdosia Rubescens, aiming to provide a foundation for further exploration of its antibacterial mechanisms and its potential in reversing bacterial resistance.
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基本信息:
中图分类号:R285
引用信息:
[1]叶林依,王艳华,刘景涛,等.冬凌草抗菌作用的研究进展[J].巴楚医学().
基金信息:
国家自然科学基金项目(81602559)
2026-06-26
2026-06-26
2026-06-26