巴楚医学

目的：研究百令胶囊治疗早期腹膜透析(EPD)患者的疗效。方法：选取2019年1月—2020年12月就诊于宜昌市中心人民医院的100例EPD患者，采用随机数字表法将其分成两组，对照组患者接受EPD治疗(n=50),观察组患者行EPD治疗的同时加服百令胶囊(n=50)。对比研究两组患者治疗三个月后的肾功能、营养状况、微炎症因子及氧化应激指标。结果：在改善肾功能方面，观察组患者残余肾功能(RRF)、24 h尿量及24 h超滤量均显著高于对照组(均P<0.05);在营养状态方面，观察组患者血清白蛋白(Alb)、前白蛋白(PA)、转铁蛋白(TRF)及血红蛋白(Hb)明显高于对照组(均P<0.05),且观察组患者的改进主观全面营养评定量表(MQSGA)明显降低(10.02±1.05分vs 12.54±2.20分，P<0.05);在微炎症指标方面，观察组血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)、血管内皮生长因子(VEGF)、转化生长因子-β1(TGF-β1)水平均明显低于对照组(均P<0.05);在氧化应激方面，观察组患者血清中丙二醛(MDA)、同型半胱氨酸(Hcy)含量较对照组均显著降低，超氧化物歧化酶(SOD)活力明显高于对照组(均P<0.05);两组患者不良反应无明显差异(P>0.05)。结论：百令胶囊可有效缓解EPD患者氧化应激反应、减轻微炎症状态，改善营养不良，提高患者的肾功能。

Objective: To study the efficacy of Bailing Capsule in the treatment of early peritoneal dialysis(EPD) patients. Methods: A total of 100 EPD patients treated in Yichang Central People's Hospital from January 2019 to December 2020 were randomly divided into two groups using a random number table method. The control group received EPD treatment(n=50), while the observation group received EPD treatment plus Bailing Capsule(n=50). Renal function, nutritional status, micro-inflammatory factors, and oxidative stress indicators were compared between the two groups after three months of treatment. Results: In terms of improving renal function, the residual renal function(RRF), 24-hour urine volume, and 24-hour ultrafiltration volume were significantly higher in the observation group than in the control group(all P<0.05). In terms of nutritional status, serum albumin(Alb), prealbumin(PA), transferrin(TRF), and hemoglobin(Hb) were significantly higher in the observation group than in the control group(all P<0.05), and the modified quantitative subjective global assessment(MQSGA) was significantly lower in the observation group(10.02±1.05 vs 12.54±2.20, P<0.05). In terms of micro-inflammatory markers, serum levels of interleukin 6(IL-6), tumor necrosis factor-α(TNF-α), hypersensitive C-reactive protein(hs-CRP), vascular endothelial growth factor(VEGF), and transforming growth factor-β1(TGF-β1) were significantly lower in the observation group than in the control group(all P<0.05). In terms of oxidative stress, serum levels of malondialdehyde(MDA) and homocysteine(Hcy) were significantly lower in the observation group than in the control group, while superoxide dismutase(SOD) activity was significantly higher in the observation group(all P<0.05). There was no significant difference in adverse reactions between the two groups(P>0.05). Conclusion: Bailing Capsule can effectively alleviate oxidative stress and micro-inflammatory status, improve malnutrition, and enhance renal function in EPD patients.